Days of Our Lives is a soap opera based primarily on the Brady and Horton families in the fictional town of Salem that first aired in November of 1965. Key cast members throughout the show’s 50-year run have included Macdonald Carey, Frances Reid, Alison Sweeney, Deidre Hall, and John Aniston. DOOL storylines have covered a wide range of topics, including serial killers, supernatural premises, back-from-the-dead characters, and core family themes. Although show ratings tend to fall below those of the other remaining soaps, Days of Our Lives viewers are a dedicated, vocal bunch who never miss an episode. The show is currently slated to stick around at least until the fall of 2016.