"You look so happy and beautiful!" one follower wrote.
"Living your best life," another added.
Another fan thought Kathie Lee appeared to be channeling her lookalike, 27-year-old daughter, in the new photo.
"Twinning Cassidy in this pic. She looks SO much like you!" a fan wrote.
The former Live co-host also shared the snap on Twitter, where she got some additional reaction from her loyal following.
"You look very peaceful and regal. Beautiful photo," one admirer tweeted.
Other followers noted that Kathie Lee seems to be all over the place in recent months.
Last month, the star posted another behind-the-scenes peek at her project in an Instagram share, which can be seen here. In the pic, Kathie Lee put on her director's hat as she worked with her collaborator, musician Billy Gaines, who plays Moses in the biblical film. At the time, the production was being shot in a field in gorgeous Antelope Lake, Utah.
She also shared an Instagram post of country and gospel singer Larry Gatlin and revealed that he blew everyone away in his role as Joshua while filming on the mountain at the Utah lake.
Kathie Lee has been keeping herself very busy juggling multiple projects over the past several months, so the pause for the casual pic at the piano appeared to be a peaceful reprieve from it all before she got back to work.
Next month, the busy entertainer will release her new book, It's Never Too Late: Make the Next Act of Your Life the Best Act of Your Life.