Weight Loss Study Says Losing Weight Reduces Proteins Associated With Cancer

Weight loss has a major impact on many diseases including cancer and diabetes. In the latest weight loss study, losing weight helps reduce the proteins associated with cancer.

Genetic Engineering & Biotechnology News reported that the new weight loss study came from the Fred Hutchinson Cancer Research Center in Seattle, Washington. What the new study revealed was that women who lost weight reduced the proteins related to angiogenesis, a process that involves the growth of blood vessels that has been linked to the growth and proliferation of cancer cells.

Catherine Duggan, Ph.D., principal staff scientist in the public health sciences division of the Fred Hutchinson Cancer Research Center said that a sedentary lifestyle combined with obesity can cause cancer.

“We know that being overweight and having a sedentary lifestyle is associated with an increase in risk for developing certain types of cancer. However, we don’t know exactly why.”

As previously reported in Inquisitr, weight loss actually has the power to reverse type 2 diabetes. The study revealed that the amount of weight loss it took to reverse the diabetes depended on the person. When patients lost the right amount of weight and then kept it off, the function of their pancreas returned to normal.

Researchers were most concerned over whether or not the weight loss would reverse diabetes for good. The results showed that even those who had type 2 diabetes for 10 years or more cured their diabetes through weight loss.

The weight loss study conducted by the Cancer Research Institute also discovered something else about health. For women who were similar sized and exercised regularly, but maintained their caloric intake and didn’t lose any weight, the study also showed the importance of diet and exercise in maintaining weight and overall good health.

The Democrat Herald reported that weight loss might reduce the risk of cancer. The proteins involved, VEGF, PAI-1 and PEDF, led to the growth of blood vessels. This process helped the blood vessels to thrive. Researchers found that the more weight women lost, the greater drop in these proteins they had.

Duggan said that weight loss reduces the risk of breast, colon and prostate cancer by as much as 20 percent. Researchers weren’t clear whether or not the proteins actually caused cancer. They were only markers for cancer. The proteins increased as weight increased. Duggan said that these proteins simply made the environment favorable for tumor growth.

“We can’t say these factors cause cancer, but we do think that these factors may make tumors grow. So if you reduce them, these dormant cancer tumors might not make the switch and start to grow, but we can’t say for sure.”

MPR reported that women who lost weight, with or without exercise, lowered their risk of cancer, and it reduced the proteins involved in the study published in Cancer Research. 439 post menopausal women, age 50 to 75, were used in the study. The groups included those who ate 2,000 calories or less and those who exercised for 45 minutes five days per week. Researchers took blood samples at the beginning and one year later.

They also adjusted for weight, age, race, and ethnicity. The women in the diet and exercise categories had a weight loss of two to 11 percent compared to women who didn’t lose weight or exercise. The authors said they saw a reduction in proteins for those who dieted and exercised.

“Weight loss is significantly associated with reduced circulating VEGF, PEDF, and PAI-1, and could provide incentive for reducing weight as a cancer prevention method in overweight and obese individuals.”

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