‘Inferno’ Trailer: Tom Hanks Returns As World Famous Symbologist Robert Langdon In Ron Howard’s Mystery Thriller [Watch]

Sony Pictures has released the new trailer for Inferno, the third mystery film starring Tom Hanks as Robert Langdon, the world’s most famous symbologist. Directed by Academy Award-winner Ron Howard and written by David Koepp, the film is based on the 2013 novel of the same name by Dan Brown. According to the synopsis, when Langdon wakes up in an Italian hospital with no memory of the past several days, he teams with Sienna Brooks (Oscar nominee Felicity Jones), a doctor he hopes will help him recover his memories. Together, they race across Europe on a trail of clues tied to the great Dante himself.

Inferno co-stars include Omar Sy, Sidse Babett Knudsen, and Irrfan Khan as Harry “The Provost” Sims, head of The Consortium. Ben Foster is also slated to star as the film’s chief villain. Inferno filmed on location in Venice, Italy, and Budapest. It’s the sequel to The Da Vinci Code, which brought in over $758 million at the worldwide box office, and Angels & Demons, which brought in over $485 million at the worldwide box office.

Inferno is scheduled to be released on October 28. Check out the trailer below.

Inferno finds Langdon has forgotten that he’s stolen the death mask of Dante Alighieri from a museum, getting himself caught up in an international plan to unleash a deadly plague. Longtime fans of Tom Hanks know that his working relationship with Ron Howard goes all the way back to Hanks’ romantic mermaid comedy, 1984’s Splash, and includes the 1995 blockbuster, Apollo 13.

Back in May, Howard told PEOPLE that Tom’s performance in Inferno is not to be missed. “This time is more personal to him for various reasons I don’t necessarily want to reveal but there’s a level of uncertainty that offsets his genius level of problem solving skills in some ways and creates great drama,” he said.

Tom Hanks, Ron Howard Angels And Demons Set [Photo by Richard Shotwell/AP Images] Hanks, HowardRon added, “The other thing about this movie that was exciting for me as a director is the Dante connection – the question of Hell and what is it? and what was it for Dante? What could it be for us today? What could society be facing? That provided me as a director a palette of imagery and possibilities, which was fun to play with and apply to this movie.”

Here’s the official Inferno synopsis.

“Academy Award winner Ron Howard returns to direct the latest bestseller in Dan Brown’s (Da Vinci Code) billion-dollar Robert Langdon series, Inferno, which finds the famous symbologist (again played by Tom Hanks) on a trail of clues tied to the great Dante himself. When Langdon wakes up in an Italian hospital with amnesia, he teams up with Sienna Brooks (Felicity Jones), a doctor he hopes will help him recover his memories. Together, they race across Europe and against the clock to stop a madman from unleashing a global virus that would wipe out half of the world’s population.”

Speaking of the exotic shooting locations of the franchise, Howard said, “Making these Dan Brown movies are amazing life experiences. You’re thrown into these environments in ways that are really stirring and kind of explosive.”

The director also told the publication that he enjoys time off set with Hanks. “He’s a tremendous artist, one of the most intelligent people in the business and he’s a world class hang,” Ron said. “So anytime we get to go out on one of these adventures and spend some time together, it’s something I always look forward to.”

Dan Brown’s Robert Langdon character also appears in the New York Times Best Seller The Lost Symbol, Brown’s 2009 literary thriller set in Washington, D.C., after the events of The Da Vinci Code. The Lost Symbol explores themes of Freemasonry and has sold 30 million copies in print worldwide.

Tom Hanks spoke about Langdon to ET online in a behind-the-scenes look at Inferno, saying, “Someone is after him and trying to kill him. So he wants to avoid being shot by a number of assassins.” Watch the ET exclusive with Hanks via the clip below.

[Photo by Pier Paolo Cito/AP Images]