Christina Applegate has now been cancer free for six years after undergoing a double mastectomy in 2008, but said the trauma of her diagnosis still gets to her sometimes.
Since her bout with breast cancer, Applegate has turned into an advocate for women's health, starting the Right Action for Women foundation to provide free MRIs for women at risk of the disease. Applegate said the organization has now spent nearly half a million dollars on MRIs.
But while the work she has done is fulfilling, Christina Applegate said her own experience is still difficult sometimes.
"It was bittersweet. You know that you are caught early, but you still have to have surgery that leaves you different for the rest of your life," she told British newspaper The Independent. "It's not an easy process. Even five-and-a-half years later I'm still having some physical issues because of it. You are constantly reminded of it, every day, you wake up and think, yep, that happened to me."
But Christina Applegate has managed to forge on with her career, appearing on television and movies including the recent Anchorman 2.
Applegate said she got along well with the male-centric cast of Will Ferrell, Steve Carell, Paul Rudd and David Koechner.
''These guys are all softies," she joked. "No machos on this set. I never felt that I was in need of a support group for women. I felt very comfortable with these guys on set. I probably have more manly qualities than most of those guys.''
Christina Applegate has a bright future as well, with voice work underway for her upcoming animated movie The Book of Life.