Study: Antibody Stops Protein That Causes Internal Bleeding

London, U.K. (AHN) – Scientists from Oklahoma and Philadelphia are poised to test in humans a new way to stop internal bleeding using antibodies that prevent a protein from destroying blood vessels.

The scientists from Oklahoma Medical Research Foundation (OMRF) and Temple University School of Medicine (TUSM) in Philadelphia will conduct the experiment following their findings that histones, which keeps DNA tightly coiled and packed inside a cell’s nuclei, are released when cells break due to injury or disease and enter the bloodstream to destroy blood vessel linings. Such action causes uncontrolled bleeding and build-up of fluid in tissues, which leads to organ failure.

The OMRF scientists learned that a monoclonal antibody found by TU researchers to stop histones can stop internal bleeding in mice with sepsis or bloodstream infection and leads to its recovery. Next they plan to test the antibody in primates and humans.

The findings of the OMRF and TUSM are published in the Sunday issue of the journal Nature Medicine

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